This study attempts to reread Isaiah 66: 16 in the light of divine justice in African Yoruba culture in Nigeria. The study survey various uses of fire in ancient Israel and in the African Yoruba tradition. In the event of justice, a parallel is sought between Yahweh and a Yoruba deified divinity called Sango whose presence is marked by fire, thunder and lightning. The parallel is with the view to establish the significance of fire on justice in African Yoruba Christianity. African Biblical Hermeneutics was used for the study. It was discovered that fire was used as medium of divine justice and mercy in African Yoruba tradition. Fire marked divine presence, manifestation of the glory of God, revelation of God’s power, cleansing of human and vessels for holy use, and use for domestic purposes especially cooking. The African Yoruba Christians in Nigeria see fire as a weapon of divine justice. Therefore, in their prayers to God they call down fire to kill their spiritual and physical enemies. They are fond of using the words: ‘die by fire’. In this way, the Bible becomes a sure and reliable weapon in the battles of life and thus makes the biblical text relevant in any context, condition and generation.